yourfanat wrote: I am using another tool for Oracle developers - dbForge Studio for Oracle. This IDE has lots of usefull features, among them: oracle designer, code competion and formatter, query builder, debugger, profiler, erxport/import, reports and many others. The latest version supports Oracle 12C. More information here.

2008 West
Data Direct
SOA, WOA and Cloud Computing: The New Frontier for Data Services
Red Hat
The Opening of Virtualization
User Environment Management – The Third Layer of the Desktop
Cloud Computing for Business Agility
CMIS: A Multi-Vendor Proposal for a Service-Based Content Management Interoperability Standard
Freedom OSS
Practical SOA” Max Yankelevich
Architecting an Enterprise Service Router (ESR) – A Cost-Effective Way to Scale SOA Across the Enterprise
Return on Assests: Bringing Visibility to your SOA Strategy
Managing Hybrid Endpoint Environments
Game-Changing Technology for Enterprise Clouds and Applications
Click For 2008 West
Event Webcasts

2008 West
Get ‘Rich’ Quick: Rapid Prototyping for RIA with ZERO Server Code
Keynote Systems
Designing for and Managing Performance in the New Frontier of Rich Internet Applications
How Can AJAX Improve Homeland Security?
Beyond Widgets: What a RIA Platform Should Offer
REAs: Rich Enterprise Applications
Click For 2008 Event Webcasts
Today's Top SOA Links

Worcester Polytechnic Institute Biologist Part of Clinical Trial Showing Tea Made from Artemisia Outperformed Drug against Tropical Disease
The authors of the multinational study conducted in the Democratic Republic of Congo recommend implementation on a global scale to treat a disease that kills 200,000 people each year.

WORCESTER, Mass., Dec. 6, 2018 /PRNewswire-PRWeb/ -- Tea infusions made from two species of the wormwood plant cured the tropical disease schistosomiasis significantly faster than the drug most commonly used against the ailment—and with no adverse side effects—in a large clinical trial conducted in the Democratic Republic of Congo. The study's authors, including a professor and two research associates at Worcester Polytechnic Institute (WPI), say the treatment should be considered for implementation on a global scale.

Schistosomiasis, which is caused by parasitic flatworms, affects nearly 210 million people worldwide, primarily in Africa, Asia, and South America, and is responsible for about 200,000 deaths each year, according to the World Health Organization. Infecting the intestines and urinary tract, it causes a range of symptoms, including abdominal pain and diarrhea, and in more severe case can lead to liver damage, kidney failure, and even bladder cancer. The only cost-effective treatment is praziquantel, or PZQ, a drug used to treat a number of parasitic worm infections.

Previous clinical trials have shown that the effectiveness of PZQ is enhanced when it is administered along with one of three anti-malarial drugs: artemisinin, artesunate, or artemether. Artemisinin is a chemical derived from the sweet wormwood plant, Artemisia annua, while the other two are chemically synthesized from artemisinin. While artesunate alone was found to be less effective than PZQ at eliminating the disease in the same trial, anecdotal reports suggest that a tea made from the Artemisia annua plant has been used successfully as a treatment for schistosomiasis.

"In preclinical studies, we showed that ingesting the dried leaves of Artemisia annua effectively eliminates the parasite that causes malaria," said Pamela Weathers, professor of biology and biotechnology at WPI, a co-author of the new study who is also currently overseeing the first clinical trial involving the use of dried leaf Artemisia (DLA) against malaria. "Some of the plant's antimalarial properties would be expected to have a similar effect on the schistosomiasis parasite, so it made sense to explore the effects of orally ingested leaves of the plant on that disease, as well."

In the study conducted by researchers in Africa, Europe, and the United States* and published in the journal Phytomedicine ("Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial," December 2018), 800 patients from Maniema Province in the Democratic Republic of Congo (DRC) who exhibited signs of schistosomiasis infection were assigned to one of three groups. One group was treated with PZQ, while patients in the other two drank about a third of a liter of a tea infusion made from the dried leaves and twigs of either Artemisia annua or Artemisia afra (another member of the wormwood genus) three times daily. Patients were considered cured when no more parasite eggs were found in their stool samples.

The results showed that both of the Artemisia tea infusions were just as effective in eliminating the parasite as PZQ, but that they achieved that result in two-thirds of the time—14 days, vs. 21 days for PZQ. And while many of the patients receiving PZQ suffered adverse side effects (more than 18 percent experienced abdominal pain, for example, and more than 26 percent had headaches), no side effects were reported among those who consumed the teas.

"This is an important study with promising results," said Lucile Cornet-Vernet, vice president of La Maison de l'Artemisia, a non-governmental organization in Paris, the corresponding author of the Phytomedicine paper. "It points to the need for more studies like this to better understand the medicinal value of Artemisia. Finding support for such studies has proven challenging, but it is important that we try, since this work benefits humanity."

Artemisia annua is categorized as a "generally recognized as safe" (GRAS) medicinal herb by the U.S. Food and Drug Administration, which means it is safe to add to foods and can be consumed without adverse effects. Made into a tea, the plant has been consumed as a remedy for malaria for hundreds of years in Asia, though it was not until 1972 that Chinese scientist Tu Youyou isolated artemisinin from the plant and demonstrated its effectiveness against malaria, a discovery that won her the 2015 Nobel Prize in Medicine.

Weathers said one of the most intriguing aspects of the results of the clinical trial in the DRC is that extracts of both species of wormwood were effective against schistosomiasis, even though only one, Artemisia annua, contains artemisinin (Artemisia afra has been found to contain, at most, trace amounts). "Each species of Artemisia contains a unique, complex mixture of phytochemicals, a number of which have been shown to have antimalarial properties," Weathers said. "The results of this study make it clear that the effectiveness of Artemisia against schistosomiasis and malaria is not due to artemisinin, alone. The plants should really be considered rich combination therapies."

In her research, Weathers has compared the effectiveness of administering the dried leaves of Artemisia annua, ground up and made into tablets or capsules, to that of the standard malarial treatment, artemisinin combination therapy, or ACT, in which artemisinin is combined with one or more other anti-malarial drugs. In animal trials, her team has shown that the body more readily absorbs artemisinin from the plant than from the drug, that the compound is less likely to be broken down by the liver, and that the plant-based therapy is more effective in eliminating the malaria parasite. Weathers believes that these differences between ACT and DLA are due to the presence of the other phytochemicals with medicinal properties in DLA.

Weathers noted that Artemisia's utility as a medicine goes beyond its demonstrated effectiveness as a treatment for schistosomiases and malaria. She said many species of wormwood, including Artemisia annua and Artemisia afra, grow naturally in areas of the world where tropical diseases are rampant and that the processes of growing, harvesting, and processing the plant and producing the DLA capsules or tablets can be done locally and even become the basis for local businesses, which could significantly lower the cost of treating these diseases and increase the availability of effective treatments.

Also, Weathers noted that while the schistosomiasis trial tested the effectiveness of tea infusions, she has chosen to focus her own studies on the efficacy of ingesting the plant, itself. "Tea infusions are the traditional way to get the benefits of Artemisia, but they have some disadvantages," she said. "First, the tea must be prepared carefully to ensure that the beneficial compounds from the plant end up in the tea, and this may not be easy for everyone to do. Second, for many people, the tea will taste very bitter, and may simply not be palatable to some patients, especially children. With the tablets and capsules containing the dried plant, the dosage can be carefully controlled, storage is possible, and most people have no problem consuming them."

Cornet-Vernet said that her organization will continue to focus on tea infusions since she believes that they offer a more affordable option for the poorest residents of Africa and other areas impacted by tropical diseases. In addition, she said the widespread problem of fraudulent medications in Africa has led her non-governmental organization to favor a treatment that people can create themselves, from plants they grow on their own property. "People in Africa are used to making tea infusions," she said. "This is something that is very familiar to them, and it can save lives."

*The full list of authors of the Phytomedicine paper: Jérôme Munyangi, Université de Kolwesi/Lualaba, DRC; Lucile Cornet Vernet of La Maison de l'Artemisia, France; Michel Idumbo, Centre de Santé de Lubile, Maniema, DRC; Pierre Lutgen, Association IVFB-BELHERB, Luxembourg; Christian Perronne, Paris IDF Ouest, France; Dieudonné Mumba, Bavon Mupenda, and Nadège Ngombe, Université de Kinshasa, DRC; Jacques Bianga, Programme National Lutte Contre le Paludisme, Maniema, DRC; Paula Lalukala, provincial minister, Santé Publique Maniema, DRC; Guy Mergeai, Université de Liège, Belgium; and Chen Lu, Melissa Towler, and Pamela Weathers, WPI.

About Worcester Polytechnic Institute

WPI, a global leader in project-based learning, is a distinctive, top-tier technological university founded in 1865 on the principle that students learn most effectively by applying the theory learned in the classroom to the practice of solving real-world problems. Recognized by the National Academy of Engineering with the 2016 Bernard M. Gordon Prize for Innovation in Engineering and Technology Education, WPI's pioneering project-based curriculum engages undergraduates in solving important scientific, technological, and societal problems throughout their education and at more than 45 project centers around the world. WPI offers more than 50 bachelor's, master's, and doctoral degree programs across 14 academic departments in science, engineering, technology, business, the social sciences, and the humanities and arts. Its faculty and students pursue groundbreaking research to meet ongoing challenges in health and biotechnology; robotics and the internet of things; advanced materials and manufacturing; cyber, data, and security systems; learning science; and more.

Alison Duffy, Director of Public Relations
Worcester Polytechnic Institute
Worcester, Massachusetts


SOURCE Worcester Polytechnic Institute

About PR Newswire
Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Web 2.0 Latest News
The developments in Google’s Cloud Computing segment, especially the Cloud Machine Learning service, have been so rapid that Google calls it one of its fastest growing product areas. Google has been ramping up their Cloud Platform quite aggressively in recent months. Just a few weeks a...
Hiring a digital marketer starts as soon as you plan to launch a prototype of your innovative idea. But, without knowing anything about digital marketing, you may not be able to reach out to investors and target audiences. You can follow the following basic points to know the significa...
When we talk about the impact of BYOD and BYOA and the Internet of Things, we often focus on the impact on data center architectures. That's because there will be an increasing need for authentication, for access control, for security, for application delivery as the number of potentia...
While walking around the office I happened upon a relatively new employee dragging emails from his inbox into folders. I asked why and was told, “I’m just answering emails and getting stuff off my desk.” An empty inbox may be emotionally satisfying to look at, but in practice, you shou...
An update to the Web Content Accessibility Guidelines (WCAG) is coming. Did I lose you already? If you're not familiar with WCAG, it's a collection of guidelines that developers, designers and accessibility experts use to help ensure the apps and websites they create are accessible to ...
Subscribe to the World's Most Powerful Newsletters
Subscribe to Our Rss Feeds & Get Your SYS-CON News Live!
Click to Add our RSS Feeds to the Service of Your Choice:
Google Reader or Homepage Add to My Yahoo! Subscribe with Bloglines Subscribe in NewsGator Online
myFeedster Add to My AOL Subscribe in Rojo Add 'Hugg' to Newsburst from CNET Kinja Digest View Additional SYS-CON Feeds
Publish Your Article! Please send it to editorial(at)!

Advertise on this site! Contact advertising(at)! 201 802-3021

SYS-CON Featured Whitepapers