yourfanat wrote: I am using another tool for Oracle developers - dbForge Studio for Oracle. This IDE has lots of usefull features, among them: oracle designer, code competion and formatter, query builder, debugger, profiler, erxport/import, reports and many others. The latest version supports Oracle 12C. More information here.
Tokyo, Jan 8, 2013 - (JCN Newswire) - Eisai Co., Ltd. announced today that it has signed an agreement with Epizyme, Inc. and Roche Molecular Systems Inc. ("RMS") to collaborate on the development of a companion diagnostic to help Eisai and Epizyme identify patients for their research on lymphomas. Specifically, the new companion diagnostic will further enable Eisai and Epizyme to advance personalized therapeutics for patients with lymphomas possessing genetic mutations in the epigenetic enzyme EZH2.
Since April 2011, Eisai has collaborated with Epizyme under a strategic partnership agreement focused on the development of cancer therapies that target EZH2 and been engaging in research aimed at the creation of such therapies. As demonstrated in a recent study conducted by Epizyme, an EZH2 inhibitor has been shown to eradicate lymphoma cells possessing change-of-function mutation in EZH2. The results of this study suggest that EZH2 is a driving oncogene in these cancers and therefore an important therapeutic target.
In parallel with the clinical development of this EZH2 inhibitor, Eisai and Epizyme are working with RMS, a company with strengths in the development and commercialization of companion diagnostics, to develop a companion diagnostic to identify a genetically defined subset of patients with lymphoma to proceed with effective clinical development.
Remarkable progress has been made in recent years in the field of oncology regarding genetics research. By maximizing full utilization of internal and external information obtained from cutting-edge research in human biology, including a drug creation approach based in genetics and epigenetics, Eisai will continue to contribute to advances in personalized therapeutics for patients with cancer.
Epigenetics refers to mechanisms that lead to activity or inactivity of selective genetic functions due to acquired genetic modification not accompanied by changes in the underlying gene sequence. The term also refers to the study of such mechanisms. Examples of acquired genetic modification in this field include changes in gene expression caused by DNA methylation and changes in genetic expression caused by the chemical modification of amino acids in histones (methylation, acetylation, phosphorylation, etc.). Dacogen(R) (decitabine), which is marketed by Eisai in the United States, is a DNA methylation inhibitor, and is approved in the United States as a therapeutic agent that contributes to the quality of life of patients living with myelodysplastic syndromes (MDS).
EZH2 is one of the proteins that make up the histone methyltransferases (HMTs) that alter gene expression. EZH2 is known to methylate lysine 27 of the protein H3 (H3K27), H3 being one of the five major histone groups (H1, H2A, H2B, H3 and H4) that together help to store DNA in eukaryotic cell nuclei. H3K27 methylation is also known to suppress gene transcription. Recently, several change-of-function genetic mutations, including Y461, have been reported in EZH2 in lymphomas.
About Eisai's Commitment to Personalized Medicine
Following advances in human biology, initiatives aimed at achievements in personalized medicine through early development of new drugs and companion diagnostics based on optimum therapeutic hypotheses are progressing steadily. Eisai is actively seeking out therapeutic hypotheses linked to personalized medicine while strengthening networks with scientists at the cutting edge of their respective fields, and is increasing its sensitivities in regard to future trends in scientific technology and both in-house and external inventions and discoveries. At its research subsidiary H3 Biomedicine Inc. in the Boston area of the United States, for example, Eisai is rising to meet challenges in targeting new therapeutic hypotheses by identifying strong potential therapeutic targets through genetics-based approaches to cancer and the creation of novel anticancer agents using first-in-class compounds. Furthermore, Eisai has concentrated all functions aimed at possible developments in this field, from biomarker discovery research to companion diagnostics development, into its Biomarker and Personalized Medicine Core Function Unit, and through collaborations with other drug creation units such as its Oncology Product Creation unit, is continuing endeavors toward further realizing personalized medicine.
About Epizyme, Inc.
Epizyme, Inc. is leading the creation of small molecule histone methyltransferase inhibitors (HMTi), a new class of personalized therapeutics for patients with genetically defined cancers. Genetic alterations in HMTs, a family of epigenetic enzymes, drive multiple human diseases. Its approach represents the future of healthcare by matching better medicines with the right patients.
Headquartered in Basel, Switzerland, Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the world's largest biotech company with truly differentiated medicines in oncology, virology, inflammation, metabolism and CNS. Roche is also the world leader in in-vitro diagnostics, tissue-based cancer diagnostics and a pioneer in diabetes management. Roche's personalized healthcare strategy aims at providing medicines and diagnostic tools that enable tangible improvements in the health, quality of life and survival of patients. In 2011, Roche had over 80,000 employees worldwide and invested over 8 billion Swiss francs in R&D. The Group posted sales of 42.5 billion Swiss francs. Genentech, United States, is a wholly owned member of the Roche Group. Roche has a majority stake in Chugai Pharmaceutical, Japan. For more information:http://www.roche.com/.
Eisai Co., Ltd. (TSE: 4523; ADR: ESALY) is a research-based human health care (hhc) company that discovers, develops and markets products throughout the world. Eisai focuses its efforts in three therapeutic areas: integrative neuroscience, including neurology and psychiatric medicines; integrative oncology, which encompasses oncotherapy and supportive-care treatments; and vascular/immunological reaction. Through a global network of research facilities, manufacturing sites and marketing subsidiaries, Eisai actively participates in all aspects of the worldwide healthcare system. For more information about Eisai Co., Ltd., please visit www.eisai.com.
Eisai Co., Ltd.
Public Relations Department
About JCN Newswire Copyright 2008 JCN Newswire. All rights reserved. Republication or redistribution of JCN Newswire content is expressly prohibited without the prior written consent of JCN Newswire. JCN Newswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.
When people think of mainframes, they typically envision ancient, obsolete technology running arcane spaghetti code – systems that IT management would love to retire if only they could free themselves from the clutches of legacy.
While there is an element of truth in this perspectiv...
Last week as I was writing Amazon Declares War on VMware, VMware was preparing to announce the acquisition of a pro services team to aid in cloud migration (see coverage in CRN): VMware Acquires Professional Services Firm To Boost Cloud Migration, DevOps Expertise. You can get my thoug...
Change is constant, and over the last decade the nexus of two trends in particular has transformed the enterprise. Mobile technology and cloud software are fundamentally changing the way we interact internally within businesses, and externally with partners and customers.
So congratulations, somehow you've managed to wangle your way onto one of the many DevOps conferences being held around the world. Why not you might say? DevOps is not only hot it's the approach many enterprises are now exploring as the means to help accelerate the delivery of high qua...
What does the data landscape look like at Facebook with its 1.3 billion users across the globe? They classify small data referring to OLTP-like queries that process and retrieve a small amount of data, usually 1-1000 objects requested by their … MORE »
Subscribe to the World's Most Powerful Newsletters
Subscribe to Our Rss Feeds & Get Your SYS-CON News Live!
Click to Add our RSS Feeds to the Service of Your Choice: