yourfanat wrote: I am using another tool for Oracle developers - dbForge Studio for Oracle. This IDE has lots of usefull features, among them: oracle designer, code competion and formatter, query builder, debugger, profiler, erxport/import, reports and many others. The latest version supports Oracle 12C. More information here.

2008 West
Data Direct
SOA, WOA and Cloud Computing: The New Frontier for Data Services
Red Hat
The Opening of Virtualization
User Environment Management – The Third Layer of the Desktop
Cloud Computing for Business Agility
CMIS: A Multi-Vendor Proposal for a Service-Based Content Management Interoperability Standard
Freedom OSS
Practical SOA” Max Yankelevich
Architecting an Enterprise Service Router (ESR) – A Cost-Effective Way to Scale SOA Across the Enterprise
Return on Assests: Bringing Visibility to your SOA Strategy
Managing Hybrid Endpoint Environments
Game-Changing Technology for Enterprise Clouds and Applications
Click For 2008 West
Event Webcasts

2008 West
Get ‘Rich’ Quick: Rapid Prototyping for RIA with ZERO Server Code
Keynote Systems
Designing for and Managing Performance in the New Frontier of Rich Internet Applications
How Can AJAX Improve Homeland Security?
Beyond Widgets: What a RIA Platform Should Offer
REAs: Rich Enterprise Applications
Click For 2008 Event Webcasts
Today's Top SOA Links

University of Florida begins iPod® trial with SPI-1005 to prevent hearing loss

GAINESVILLE, Fla., Dec. 5, 2012 /PRNewswire/ -- The University of Florida (UF) has started enrolling subjects in a new study testing the oral drug developed by Sound Pharmaceuticals, Inc. (SPI-1005) to prevent hearing loss caused by loud music. Loud music or noise can induce temporary and permanent auditory threshold shifts (TTS or PTS). As people age, the level of PTS grows and results in a moderate loss of speech perception and discrimination, especially in noisy environments. In this Phase-II interventional clinical trial, volunteers will listen to pre-selected music delivered using an iPod® and insert earphones providing an exposure that results in small but reliable temporary threshold shifts. Volunteers will take a placebo or SPI-1005 before and after this exposure, to assess the extent to which TTS is reduced, and/or the rate of recovery is accelerated. SPI-1005 is an oral capsule that contains ebselen, a synthetic molecule that mimics the activity of Glutathione Peroxidase (GPx), a critical enzyme in the inner ear that protects it from damage caused by loud sounds or noise. In animal studies, GPx decreases in several important auditory structures including hair cells, supporting cells, nerve and lateral wall structures such as the stria vascularis. In several preclinical studies, ebselen treatment was shown to improve the GPx levels within these structures and to reduce the TTS and PTS induced by loud noise.

"The goal of this clinical trial is to determine if SPI-1005 can prevent or reduce the TTS induced by listening to loud music," said Dr. Colleen Le Prell, PhD, Associate Professor and Lead Investigator at the UF College of Public Health and Health Professions' Department of Speech, Language, and Hearing Sciences.

Currently there are no FDA approved drugs for the prevention and treatment of sensorineural hearing loss. "The enrollment of this Ph-II study represents a significant milestone for SPI and we are excited to advance of our clinical programs to achieve proof of concept in man" said Eric Lynch, PhD, President, SPI. Details of the study can be viewed online at by searching SPI-1005.

SPI is a privately held biopharmaceutical company in Seattle with a focus on developing the first drugs for the prevention and treatment of hearing loss.

Please visit
Eric Lynch, PhD, President, Sound Pharmaceuticals, Inc.
4010 Stone Way N Suite 120, Seattle WA 98103 Office: 206-634-2559



SOURCE Sound Pharmaceuticals, Inc.

About PR Newswire
Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Web 2.0 Latest News
While walking around the office I happened upon a relatively new employee dragging emails from his inbox into folders. I asked why and was told, “I’m just answering emails and getting stuff off my desk.” An empty inbox may be emotionally satisfying to look at, but in practice, you shou...
An update to the Web Content Accessibility Guidelines (WCAG) is coming. Did I lose you already? If you're not familiar with WCAG, it's a collection of guidelines that developers, designers and accessibility experts use to help ensure the apps and websites they create are accessible to ...
Hiring a digital marketer starts as soon as you plan to launch a prototype of your innovative idea. But, without knowing anything about digital marketing, you may not be able to reach out to investors and target audiences. You can follow the following basic points to know the significa...
Java 9 ships with some minor—yet awesome—new language features that make developing easier and cleaner. In this post, we’ll take a look at three of these new features. You probably remember interface methods, which were introduced in Java 8. These are required so that Java itself, as ...
Digital transformation has changed the way users interact with the world, and the traditional healthcare experience no longer meets rising consumer expectations. Enterprise Health Clouds (EHCs) are designed to easily and securely deliver the smart and engaging digital health experience...
Subscribe to the World's Most Powerful Newsletters
Subscribe to Our Rss Feeds & Get Your SYS-CON News Live!
Click to Add our RSS Feeds to the Service of Your Choice:
Google Reader or Homepage Add to My Yahoo! Subscribe with Bloglines Subscribe in NewsGator Online
myFeedster Add to My AOL Subscribe in Rojo Add 'Hugg' to Newsburst from CNET Kinja Digest View Additional SYS-CON Feeds
Publish Your Article! Please send it to editorial(at)!

Advertise on this site! Contact advertising(at)! 201 802-3021

SYS-CON Featured Whitepapers