Comments
yourfanat wrote: I am using another tool for Oracle developers - dbForge Studio for Oracle. This IDE has lots of usefull features, among them: oracle designer, code competion and formatter, query builder, debugger, profiler, erxport/import, reports and many others. The latest version supports Oracle 12C. More information here.

2008 West
DIAMOND SPONSOR:
Data Direct
SOA, WOA and Cloud Computing: The New Frontier for Data Services
PLATINUM SPONSORS:
Red Hat
The Opening of Virtualization
GOLD SPONSORS:
Appsense
User Environment Management – The Third Layer of the Desktop
Cordys
Cloud Computing for Business Agility
EMC
CMIS: A Multi-Vendor Proposal for a Service-Based Content Management Interoperability Standard
Freedom OSS
Practical SOA” Max Yankelevich
Intel
Architecting an Enterprise Service Router (ESR) – A Cost-Effective Way to Scale SOA Across the Enterprise
Sensedia
Return on Assests: Bringing Visibility to your SOA Strategy
Symantec
Managing Hybrid Endpoint Environments
VMWare
Game-Changing Technology for Enterprise Clouds and Applications
Click For 2008 West
Event Webcasts

2008 West
PLATINUM SPONSORS:
Appcelerator
Get ‘Rich’ Quick: Rapid Prototyping for RIA with ZERO Server Code
Keynote Systems
Designing for and Managing Performance in the New Frontier of Rich Internet Applications
GOLD SPONSORS:
ICEsoft
How Can AJAX Improve Homeland Security?
Isomorphic
Beyond Widgets: What a RIA Platform Should Offer
Oracle
REAs: Rich Enterprise Applications
Click For 2008 Event Webcasts
SYS-CON.TV
Today's Top SOA Links


Neuralstem Reports Third Quarter Financial Results And Provides Update On Clinical Programs And Business Highlights

ROCKVILLE, Md., Nov. 9, 2012 /PRNewswire/ -- Neuralstem, Inc. (NYSE MKT: CUR) reported its financial results for the three months and nine months ended September 30, 2012 and provided an update on clinical programs and business highlights.

(Logo:  http://photos.prnewswire.com/prnh/20061221/DCTH007LOGO )

"In the third quarter, the company achieved three significant clinical milestones. The first was the completion of the eighteenth and final surgery in our ALS Phase I trial. All ALS trial assessments show the NSI-566 neural stem cells and intraspinal transplantation procedure, the first in the world, to be safe. The trial's principal investigator, Dr. Eva Feldman, said she believes we are seeing evidence of a treatment effect in some Phase I patients over a sustained period of time. We look forward to advancing to the next ALS trials, to increase both number of patients treated and NSI-566 dosage, and effectively evaluate efficacy. To that end, we are working diligently with our investigators to file an IND with the FDA for a Phase II ALS trial by year-end," said Karl Johe, PhD, Chairman of Neuralstem's Board of Directors and Chief Scientific Officer.

"The second significant clinical milestone was approval to begin our ischemic stroke trial in China. Our collaborators in Beijing, at the world-class BaYi Brain Hospital are on schedule to start enrollment early in the first quarter for a combined Phase I/II clinical trial to treat motor deficits due to ischemic stroke with NSI-566. The first part of the study, Phase I, will be open-label and enroll up to 18 patients who will be assigned to one of three cohorts. Each cohort will receive ascending doses of NSI-566 directly into the brain at the stroke area (another first for Neuralstem), to define the maximal safe dose, before proceeding to the Phase II/proof-of-concept study to evaluate efficacy," said Dr. Johe. "One of several independent Neuralstem studies presented at The Society for Neuroscience's annual meeting demonstrated significant recovery of motor and neurological functions in ischemic stroke rats with NSI-566; a second ischemic stroke study demonstrated safety and feasibility in a chronic model in mini-pigs. Together, with the extensive human safety data established in our ALS trial, these two studies demonstrate strong proof-of-principle data that our NSI-566 cells are ready to test in humans to treat paralysis in stroke patients. A rat spinal cord injury study, reported in the peer-reviewed scientific journal CELL, demonstrated that NSI-566 cells induce regeneration of injured spinal cord axons into the graft and serve as a bridge to reconnect to gray matter motor neurons for many spinal cord segments below an injury, inducing significant recovery of motor functions."

Dr. Johe concluded: "The third significant clinical milestone was the FDA approval for dosing the second cohort of major depressive disorder patients in the Phase Ib trial of NSI-189. Our lead neurogenic drug, NSI-189 is a first-in-class orally active drug that stimulates new neuron growth and increased volume in the hippocampus, which we believe can help patients with MDD and other psychological and cognitive conditions. We are on track to complete the Ib, an ascending-dose, 28-day-cycle safety trial designed in collaboration with Dr. Maurizio Fava of Harvard University and Massachusetts General, during the first quarter of 2013."

Neuralstem's President and CEO Richard Garr added: "The third quarter of 2012 marked business milestones as well. We saw a major addition to our patent estate with U.S. patent number 8,236,299, with a patent life into 2030, titled: 'Transplantation of Human Neural Cells for Treatment of Neurodegenerative Conditions.' This is significant in that it covers processes involved in our first potential transplantation product, including claims covering processes for dissociating our neural stem cells from central nervous system tissue; culturing the cells; expanding the cells in vitro and transplanting the cells into the spinal cord of a patient to treat a wide array of neurodegenerative conditions, including ALS."

Mr. Garr continued: "The company granted its first licenses for use of our proprietary Spinal Cord Delivery Platform and Floating Cannula. As the industry standard for delivering therapeutic agents to the spinal cord, we expect to continue to announce licenses of the surgical devices to both industry and academia as they now begin to explore the possibilities our technology has enabled. We are also continuing discussions for licensing and partnership opportunities for our neurogenic small molecule program, for which we are seeing strong interest. Our goal is to move NSI-189 and our preclinical library of additional novel neurogenic compounds forward in multiple indications, which range from Alzheimer's disease and anti-aging (nootropic) to chronic traumatic encephalopathy and post-traumatic stress disorder. We believe this can best be accomplished through partnering with industry."

Clinical Program and Business Highlights

Cellular Therapy: NSI-566 Phase I Clinical Trial in ALS (amyotrophic lateral sclerosis, or Lou Gehrig's disease) at Emory University Hospital

  • In August, Neuralstem completed the final transplantation of its ground-breaking Phase I safety trial of NSI-566 spinal cord neural stem cells for the treatment of ALS. Phase I is scheduled to conclude six months after this final surgery of returning patient #18.
  • In July, patient 17 was the second ALS patient to return to the trial, receiving five injections in the cervical region in addition to the ten previously received in the lumbar region of the spinal cord, for a total of 15 injections of neural stem cells.
  • Subsequent Event:  In October, principal investigator and president of the American Neurological Association (ANA) Eva Feldman, MD, PhD, updated data on the trial at the ANA annual meeting. She called the transplantations "a paradigm shift in the treatment of ALS" and presented interim results on all 18 procedures in 15 patients.

Cellular Therapy: NSI-566 Phase I/II Clinical Trial in Ischemic Stroke at BaYi Brain Hospital

  • In August, Neuralstem was approved to commence a clinical trial to treat motor deficits due to ischemic stroke with NSI-566 at BaYi Brain Hospital, in Beijing, China, through its subsidiary, Neuralstem China. The trial approval includes a combined phase I/II design of up to 118 patients, and will test direct injections into the brain of NSI-566. It is scheduled to commence in the first quarter of 2013.

Cellular Therapy: NSI-566 Pre-clinical Programs

  • In September, a peer-reviewed article in the leading scientific journal CELL reported that Neuralstem NSI-566 cells induced significant functional improvement in permanent rat spinal cord injury, with paralyzed rats regaining use of lower limbs. The study, entitled "Long-Distance Growth and Connectivity of Neural Stem Cells After Severe Spinal Cord Injury: Cell-Intrinsic Mechanisms Overcome Spinal Inhibition," reports that the animals recovered significant locomotor function, regaining movement in all lower extremity joints, and that the transplanted neural stem cells turned into neurons which grew a "remarkable" number of axons that extended for "very long distances" over 17 spinal segments, making connections both above and below the point of severance.
  • Subsequent Event: In October, NSI-566/animal ischemic stroke data was presented in two independent studies at The Society for Neuroscience's Annual Meeting. "Histopathological Assessment of Adult Ischemic Rat Brains after 4 Weeks of Intracerebral Transplantation of NSI-566RSC Cell Line," conducted in the laboratory of Dr. Cesar Borlongan at the Center of Excellence for Aging and Brain Repair at the University of South Florida College of Medicine, showed significant recovery of motor and neurological functions in ischemic stroke rats with NSI-566. The other ischemic stroke study presented was conducted by Dr. Martin Marsala at the Neuroregeneration Laboratory at University of California San Diego, and entitled "Survival and Differentiation of Human Neural Stem Cells (NSI-566RSC) After Grafting into Ischemia-Injured Porcine Brain."  Neuralstem presented three additional posters of preclinical data at the meeting.

Neurogenic Small Molecule NSI-189: Phase I Clinical Trial in Major Depressive Disorder (MDD)

  • Subsequent Event: In October, Neuralstem began dosing the second cohort of eight patients, upon receiving FDA approval, in the Phase Ib trial. The trial is testing the safety of escalated dosing for 28 daily administrations of the company's lead neurogenic small molecule drug, NSI-189, in the treatment of major depressive disorder.

Corporate News

  • In September, Neuralstem granted the first licenses for use of its Spinal Cord Delivery Platform and Floating Cannula, used in the ALS Phase I trial for delivering therapeutic agents to the spinal cord.
  • In September, Chairman and Chief Scientific Officer Dr. Karl Johe presented "Novel Neurogenic Drugs Targeting Hippocampal Degeneration" at the 6th Neurodegenerative Conditions Research and Development conference, and President and CEO Richard Garr presented corporate and clinical updates at the 2012 Aegis Healthcare Conference and the 2012 Rodman and Renshaw Annual Healthcare Conference.
  • In July, Neuralstem received a notice of issuance for patent application number 12/710,097 (subsequently issued patent number 8,236,299) titled: "Transplantation of Human Neural Cells for Treatment of Neurodegenerative Conditions." This patent, which will expire in the first quarter of 2030, covers both the culturing of central nervous system (CNS) cells as well as their transplantation into spinal cord tissue to treat neurodegenerative conditions, including ALS.
  • During the quarter, the company raised $9.76 million through offerings of its common stock to fund its ongoing clinical trials, research and development, and working capital.
  • Subsequent Events: In October, Neuralstem engaged Locust Walk Partners, LLC, a life sciences' commercial licensing and partnering specialist advisory firm, to further explore partnership opportunities for a clinical-stage neurogenic small molecule program targeting a broad range of psychiatric and cognitive disorders.
  • Subsequent Events: In October, Neuralstem received a notice of issuance for Vietnam patent number 10524 titled: "Transplantation of Human Neural Cells for Treatment of Neurodegenerative Conditions." This issuance brings Neuralstem's worldwide patent count to 28 issued and 43 pending.

Third Quarter Financial Results

For the third quarter of 2012, the Company reported a net loss of $2,577,391 or $0.04 per share, compared with a net loss of $3,211,604 or $0.07 per share, for the comparable 2011 period.  The decrease in net loss was primarily due to an approximately $698,000 reduction in project expenses related to studies which ended in 2011 coupled with a decrease in non-cash stock based compensation expense of approximately $181,000 partially offset by increases in consulting expenses. In addition, in the third quarter of 2012, the Company recognized approximately $171,000 in revenue from third-party licenses agreements.

For the nine months ended September 30, 2012, the Company reported a net loss of $7,406,553, or $0.14 per share, compared with a net loss of $9,962,131 or $0.21 per share for the comparable 2011 period. The decrease in net loss was primarily due to a reduction in non-cash stock based compensation expense of approximately $1,700,000 coupled with decreases of approximately $617,000 in project expenses and $355,000 in legal expenses and an increase in revenues of approximately $302,000 partially offset by gains of approximately $412,000 related to a legal settlement and changes in the fair value of certain warrant obligations in 2011.

Cash and cash equivalents on hand at September 30, 2012 totaled $9,873,395, compared with $2,352,013 at December 31, 2011. The approximately $7,521,000 increase in cash and cash equivalents over the nine months of 2012 was primarily due to approximately $13,685,000 of net proceeds from the issuance of common stock during the nine months ended September, 2012 partially offset by cash used in operations.

About Neuralstem

Neuralstem's patented technology enables the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, and the ability to control the differentiation of these cells constitutively into mature, physiologically relevant human neurons and glia. Neuralstem has recently treated the last patient in an FDA-approved Phase I safety clinical trial for amyotrophic lateral sclerosis (ALS), often referred to as Lou Gehrig's disease, and has been awarded orphan status designation by the FDA.

In addition to ALS, the company is also targeting major central nervous system conditions with its NSI-566 cell therapy platform, including spinal cord injury, ischemic stroke and glioblastoma (brain cancer). The company has submitted an IND (Investigational New Drug) application to the FDA for a Phase I safety trial in spinal cord injury.

Neuralstem also has the ability to generate stable human neural stem cell lines suitable for the systematic screening of large chemical libraries. Through this proprietary screening technology, Neuralstem has discovered and patented compounds that may stimulate the brain's capacity to generate new neurons, possibly reversing the pathologies of some central nervous system conditions.  The company is in a Phase Ib safety trial evaluating NSI-189, its first neurogenic small molecule compound, for the treatment of major depressive disorder (MDD). Additional indications could include chronic traumatic encephalopathy (CTE), Alzheimer's disease, and post-traumatic stress disorder (PTSD).

For more information, please visit www.neuralstem.com or connect with us on Twitter and Facebook.

Cautionary Statement Regarding Forward Looking Information            

This news release may contain forward-looking statements made pursuant to the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Investors are cautioned that such forward-looking statements in this press release regarding potential applications of Neuralstem's technologies constitute forward-looking statements that involve risks and uncertainties, including, without limitation, risks inherent in the development and commercialization of potential products, uncertainty of clinical trial results or regulatory approvals or clearances, need for future capital, dependence upon collaborators and maintenance of our intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements. Additional information on potential factors that could affect our results and other risks and uncertainties are detailed from time to time in Neuralstem's periodic reports, including the annual report on Form 10-K for the year ended December 31, 2011 and the quarterly report on Form 10-Q for the period ended September 30, 2012.

 

Neuralstem, Inc.





Unaudited Condensed Balance Sheets






September 30, 2012


December 31, 2011





ASSETS




CURRENT ASSETS




Cash and cash equivalents

$           9,873,395


$        2,352,013

Prepaid expenses

289,788


430,356

Billed and unbilled receivables

833


234,375





Total current assets

10,164,016


3,016,744





Property and equipment, net

246,017


292,193

Patent filing fees, net

772,186


701,846

Other assets

59,533


75,394





Total assets

$         11,241,752


$        4,086,177





LIABILITIES AND STOCKHOLDERS' EQUITY








CURRENT LIABILITIES








Accounts payable and accrued expenses 

$           1,501,345


$        1,843,684

Accrued bonus expense

479,368


582,675

Other current liabilities

138,987


-





Total current liabilities

2,119,700


2,426,359





Deferred rent, net of current portion

23,750


-





Total liabilities

2,143,450


2,426,359





Commitments and contingencies (Note 5)








STOCKHOLDERS' EQUITY








Preferred stock, 7,000,000 shares authorized, zero shares issued and outstanding

-


-

Common stock, $0.01 par value; 150 million shares authorized, 67,964,314 and 48,682,118 shares outstanding in 2012 and 2011,respectively

679,643


486,821

Additional paid-in capital

114,297,870


99,645,655

Accumulated deficit

(105,879,211)


(98,472,658)

Total stockholders' equity

9,098,302


1,659,818





Total liabilities and stockholders' equity

$         11,241,752


$        4,086,177





 

Neuralstem, Inc.









Unaudited Condensed Statements of Operations






Three Months Ended September 30,


Nine Months Ended September 30,


2012


2011


2012


2011









Revenues

$                          170,833


$                  103,417


$                      405,208


$                    103,417









Operating expenses:








Research and development costs

1,385,478


2,124,204


4,406,538


5,948,603

General and administrative expenses

1,280,606


1,137,995


3,264,146


4,433,703

Depreciation and amortization

87,908


64,285


164,154


149,548

Total operating expenses

2,753,992


3,326,484


7,834,838


10,531,854

Operating loss

(2,583,159)


(3,223,067)


(7,429,630)


(10,428,437)









Other income (expense):








Litigation settlement

692


-


3,265


250,000

Interest income

5,411


11,463


21,601


54,497

Interest expense

(335)


-


(1,789)


-

Gain from change in fair value of warrant obligations

-


-


-


161,809

Total other income (expense) 

5,768


11,463


23,077


466,306









Net loss

$                      (2,577,391)


$             (3,211,604)


$                  (7,406,553)


$               (9,962,131)









Net loss per share - basic and diluted

$                               (0.04)


$                      (0.07)


$                           (0.14)


$                        (0.21)









Weighted average common shares outstanding - basic and diluted

58,363,721


48,488,432


54,751,377


48,225,452









 

SOURCE Neuralstem, Inc.

About PR Newswire
Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Web 2.0 Latest News
There are a variety of opinions on the seriousness of Heartbleed being put forth ranging from "it's not the end of the world" to "the sky is falling, duck and cover." Usually the former cites the relatively low percentage of sites impacted by Heartbleed, pegged at about 17% or 500,000 ...
HTML5 is still one of the most discussed topics amongst us technical types. The key challenge, however, has remained unanswered for a long time. How do you effectively wrap HTML5 for use in native mobile applications? Unfortunately I do not have a universal answer, but I do have a s...
If the CEO of the company has anything to say about Lenovo's standing in the PC industry, the company won't stop until massive growth is achieved. In a series of recent buying sweeps, Lenovo has bought Motorola Mobility for a whopping $2.91 billion from Google and also acquired the ser...
Zetta.net is an enterprise-grade backup and disaster recovery provider. We have been in business for over five years, and we have over 800 enterprise customers and managed service providers (MSPs) that use or resell our product, as is the case with MSPs. In terms of the IT challenges,...
What is the “3rd Platform” of IT? It comprises of the cloud, mobile, social, and big data products. According to IDC, “3rd Platform technologies and solutions will drive 29 percent of 2014 IT spending and 89 percent of all IT spending growth”. Much of that growth will come from the “ca...
Subscribe to the World's Most Powerful Newsletters
Subscribe to Our Rss Feeds & Get Your SYS-CON News Live!
Click to Add our RSS Feeds to the Service of Your Choice:
Google Reader or Homepage Add to My Yahoo! Subscribe with Bloglines Subscribe in NewsGator Online
myFeedster Add to My AOL Subscribe in Rojo Add 'Hugg' to Newsburst from CNET News.com Kinja Digest View Additional SYS-CON Feeds
Publish Your Article! Please send it to editorial(at)sys-con.com!

Advertise on this site! Contact advertising(at)sys-con.com! 201 802-3021




SYS-CON Featured Whitepapers
ADS BY GOOGLE